Premium
Prostaglandin E 2 and treatment outcome in pulp therapy of primary molars with carious exposures
Author(s) -
Waterhouse P. J.,
Nunn J. H.,
Whitworth J. M.
Publication year - 2002
Publication title -
international journal of paediatric dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.183
H-Index - 62
eISSN - 1365-263X
pISSN - 0960-7439
DOI - 10.1046/j.1365-263x.2002.00321.x
Subject(s) - medicine , molar , pulp (tooth) , dentistry , pulpitis , coronal plane , root canal , radiological weapon , surgery , radiology
Summary. Objectives. Prostaglandin E 2 (PGE 2 ) has been suggested as an indicator of irreversible pulpitis in permanent teeth [1]. There is scant information on the role of chemical mediators in primary molar pulp inflammation. The aim of this preliminary study was to investigate the levels of PGE 2 in blood harvested from root pulp stumps following coronal pulp amputation in vital primary molar teeth with carious exposures. Methods. Seventy‐nine cariously exposed primary molars underwent treatment by one of two vital pulp therapy techniques. Blood was harvested from 38 teeth and volume and concentration of PGE 2 ([PGE 2 ]) determined [2]. Treatment outcome was assessed from both clinical and radiographic evidence. Results. PGE 2 was detected in all samples, with a wide concentration range (1–2641 ng/mL). The distribution was skewed, requiring log transformation. The difference in the mean (log) [PGE 2 ] for radiological success (3·12, SD 1·60) and failure (4·62, SD 1·80) was significant, t = 2·05, P = 0·047. The difference in the mean (log) [PGE 2 ] for clinical success (3·24, SD 1·65) and failure (5·44, SD 1·43) was near‐significant, t = 1·84, P = 0·074. Conclusion. [PGE 2 ] correlated positively with radiological outcome following vital pulp therapy.