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Aspects of 2‐acetyl‐1,3‐cyclopentanedione as a chromium( iii ) chelating agent: nutritional implications
Author(s) -
Blanco Carlos,
Rojas Antonio,
Gomez Manuel,
Ronda Felicidad,
Caballero Pedro
Publication year - 2003
Publication title -
international journal of food science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 96
eISSN - 1365-2621
pISSN - 0950-5423
DOI - 10.1046/j.1365-2621.2003.00629.x
Subject(s) - chromium , chelation , chemistry , tautomer , metal , ligand (biochemistry) , enol , bioavailability , metal ions in aqueous solution , aqueous solution , inorganic chemistry , nuclear chemistry , medicinal chemistry , organic chemistry , biochemistry , bioinformatics , catalysis , receptor , biology
Summary The chemistry of 2‐acetyl‐1,3‐cycloalkanediones has acquired increased applied importance because of the great number of applications in the agroalimentary industry. The keto‐enol ratios and equilibrium constants for proton reactions of 2‐acetyl‐1,3‐cyclopentanedione have been determined in solution using nuclear magnetic resonance and spectrophotometric methods. Chromium( iii ) is an essential nutrient and it seems that high chromium supplementation improves glucose tolerance. Chromium chelates have been shown to have a significant beneficial effect on metal status by increasing metal bioavailability in human diets. The composition and log β‐value of the complex formed in aqueous solution by chromium( iii ) with the ligand mentioned above have been determined. A detailed reaction scheme is proposed for the 1 : 1 chelation process. The kinetic data are consistent with a mechanism in which the mono‐enol tautomer of the ligand reacts with both metallic species, the fully hydrated metal ion and the Cr(OH) 2+ . The results are discussed in the light of previous work.