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The effect of IFNγ on the hepatocyte: cell cycle and apoptosis
Author(s) -
Tura Benjamin J.,
Bunyan Kerry E.,
Harrison David J.
Publication year - 2001
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1046/j.1365-2613.2001.00207.x
Subject(s) - apoptosis , hepatocyte , caspase , cell cycle checkpoint , cell cycle , microbiology and biotechnology , cytokine , cancer research , interferon gamma , chemistry , biology , immunology , programmed cell death , biochemistry , in vitro
The inflammatory cytokine interferon gamma (IFNγ) can cause cell cycle arrest and apoptosis in the hepatocyte. Primarily these processes are protective but in chronic liver disease oncogenic mutations may prosper. IFNγ signalling is discussed showing how p53 is induced to cause cell cycle arrest. While caspases are are known to be responsible for IFNγ induced apoptosis, how they are activated is unclear. Potential mechanisms are reviewed.