Premium
Animal models of acute hepatic failure
Author(s) -
Manibur Rahman Tony
Publication year - 2000
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1046/j.1365-2613.2000.00144.x
Subject(s) - liver failure , medicine , liver transplantation , intensive care medicine , acute hepatic failure , animal model , intervention (counseling) , transplantation , bioinformatics , biology , psychiatry
The understanding and treatment of acute hepatic failure has developed rapidly over the last 40 years reducing morbidity and mortality from this syndrome. Progress has been made by the study of animal models that reflect the clinical, biochemical and histological pattern of the syndrome seen in man. This is of increasing importance with the use of therapeutic intervention, liver transplantation and the use of extra‐corporeal liver support devices. This review examines and critically appraises the various approaches to the study of acute hepatic failure in animal models, including both surgical and pharmacological approaches.