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Cytokines and their receptors in cardiovascular diseases — role of gp130 signalling pathway in cardiac myocyte growth and maintenance
Author(s) -
Keiko Yamauchi–Takihara,
Tadamitsu Kishimoto
Publication year - 2000
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1046/j.1365-2613.2000.00139.x
Subject(s) - glycoprotein 130 , cardiac myocyte , myocyte , signal transduction , receptor , stat , microbiology and biotechnology , medicine , kinase , jak stat signaling pathway , signalling , endocrinology , biology , cytokine , interleukin 6 , stat3 , tyrosine kinase
Interleukin (IL)‐6‐related cytokines share gp130 as the signal‐transducing protein. Cardiac myocytes produce various kinds of cytokines including IL‐6 and cardiotrophin‐1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI‐3 kinase pathways. Besides various well‐established mechanisms by which cardiac growth and myocardial remodeling are regulated, gp130 signalling may be a newly discovered mechanism that regulates these events in association with cytoprotective effect in myocardial diseases.