Premium
Hepatocyte growth factor/scatter factor‐induced intracellular signalling
Author(s) -
Stuart Katherine A.,
Riordan Stephen M.,
Lidder Sukhwinderjit,
Crostella Luca,
Williams Roger,
Skouteris George G.
Publication year - 2000
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1046/j.1365-2613.2000.00138.x
Subject(s) - hepatocyte growth factor , intracellular , microbiology and biotechnology , hepatocyte , factor (programming language) , growth factor , signalling , chemistry , biology , biochemistry , computer science , receptor , in vitro , programming language
Hepatocyte growth factor (HGF) identical to scatter factor (SF) is a glycoprotein involved in the development of a number of cellular phenotypes, including proliferation, mitogenesis, formation of branching tubules and, in the case of tumour cells, invasion and metastasis. This fascinating cytokine transduces its activities via its receptor encoded by the c‐ met oncogene, coupled to a number of transducers integrating the HGF/SF signal to the cytosol and the nucleus. The downstream transducers coupled to HGF/MET, most of which participate in overlapping pathways, determine the development of the cell's phenotype, which in most cell types is dual.