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Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin‐2 receptor γ chain‐deficient mice
Author(s) -
Ikebe Mika,
Miyakawa Kazuhisa,
Takahashi Kiyoshi,
Ohbo Kazuyuki,
Nakamura Masataka,
Sugamura Kazuo,
Suda Toshio,
Yamamura Kenichi,
Tomita Kimio
Publication year - 1997
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1046/j.1365-2613.1997.230356.x
Subject(s) - biology , mesenteric lymph nodes , spleen , haematopoiesis , lymphatic system , lymphopoiesis , germinal center , pathology , immunology , b cell , endocrinology , stem cell , antibody , medicine , genetics
Interleukin‐2 (IL‐2) receptor γ chain‐deficient mice with a truncated mutation showed the absence or severe reduction of natural killer cells, decreased numbers of T‐ and B‐ cells, marked hypoplasia of the thymus and peripheral lymphoid tissues, defective formation of lymphoid follicles and germinal centre in the peripheral lymphoid tissues, and the absence of Peyer's patches in the intestinal mucosa. In addition, marked splenomegaly with extramedullary haematopoiesis, increased level of IgM and decreased levels of IgG and IgE in serum, severe reduction of conventional B cells (B‐2) in the peripheral lymphoid tissues, the presence of IgM‐producing CD5 + B cells (B‐1) and their differentiation into plasma cells and Motto cells in the spleen, and increased production and differentiation of macrophages in various tissues were found in the mutant mice. However, the development of both marginal metallophilic macrophage populations in the spleen and of their related macrophages in the other tissues of the mutant mice was severely impaired. All these abnormalities seem to be induced by the loss‐of‐function of the IL‐2 receptor γ chain. From 8 weeks of age on, inflammatory changes occurred in the intestines, mesenteric lymph nodes, lungs, liver, and kidneys of the mutant mice. Besides the absence of Hassall’s corpuscles, thymic cysts were frequently observed in the mutant mice. These pathological abnormalities suggest that the γ chain is implicated not only in lymphoid and haematopoietic development but also in thymic epithelial cell ontogeny.