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7,12‐Dimethylbenz[ a ]anthracene‐induced ‘early’ squamous cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with ‘early’ forms of human squamous cell carcinoma in the upper aero‐digestive tract
Author(s) -
ANDREJEVIC S.,
SAVARY JF.,
FONTOLLIET C.,
MONNIER Ph.,
VAN DEN BERGH H.
Publication year - 1996
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1046/j.1365-2613.1996.956095.x
Subject(s) - cheek pouch , hamster , golden hamster , 7,12 dimethylbenz[a]anthracene , basal cell , immunohistochemistry , pathology , cancer , biology , histology , carcinoma , cheek , medicine , cancer research , dmba , carcinogenesis , anatomy
To test and optimize photodynamic therapy of early cancers in the upper aero‐digestive tract and oesophagus, we sought an appropriate animal model, which was found in the 7,12‐dimethylbenz[ a ]anthracene‐induced early squamous cell carinoma in the Golden Syrian hamster. This chemically induced neoplasm is shown, by histology and immunohistochemistry, to pass through similar stages of early cancer development as its human counterpart. Its time sequence is highly reproducible, leading to a well differentiated carcinoma in situ and microinvasive carcinoma in the hamster cheek pouch over a period of 10 weeks.