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Analysis of genetic variability in Anopheles arabiensis and Anopheles gambiae using microsatellite loci
Author(s) -
Field L. M.,
James A. A.,
Kamau L.,
Mukabana W. R.,
Hawley W. A.,
Lehmann T.,
Irungu L. W.,
Orago A. A. S.,
Collins F. H.
Publication year - 1999
Publication title -
insect molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.955
H-Index - 93
eISSN - 1365-2583
pISSN - 0962-1075
DOI - 10.1046/j.1365-2583.1999.820287.x
Subject(s) - anopheles gambiae , biology , gene flow , microsatellite , allele , null allele , zoology , evolutionary biology , genetics , genetic variation , gene , malaria , immunology
Abstract We analysed genetic variability in Anopheles arabiensis and Anopheles gambiae populations using micro‐satellite loci to determine whether the Rift Valley restricts the flow of genes. Deviations from Hardy–Weinberg expectations were significant, and were most likely to be due to the high frequency of null alleles observed. An. arabiensis populations occurring between 40 and 700 km apart across the Eastern arm of the Rift Valley were not differentiated (pair‐wise F st range: 0.0033–0.0265, P > 0.05). Neither were An. gambiae populations from Asembo Bay and Ghana ( F st : 0.0063, P > 0.05) despite a geographical separation of about 5000 km. In contrast, significant differentiation was observed between An. gambiae populations from Asembo Bay and Kilifi (about 700 km apart; F ST = 0.1249, P < 0.01), suggesting the presence of a barrier to gene flow.