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Allograft inflammatory factor‐1 regulates trinitrobenzene sulphonic acid‐induced colitis
Author(s) -
Morohashi Taiki,
Iwabuchi Kazuya,
Watano Keiko,
Dashtsoodol Nyambayar,
Mishima Tetsuya,
Nakai Yukihito,
Shimada Shigeki,
Nishida Ryutaro,
Fujii Satoshi,
Onoé Kazunori
Publication year - 2003
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.2003.01714.x
Subject(s) - colitis , inflammatory bowel disease , genetically modified mouse , medicine , immunology , lesion , inflammation , transgene , chemistry , pathology , disease , biochemistry , gene
Summary The expression of allograft inflammatory factor‐1 (AIF‐1) in 2,4,6‐trinitrobenzene sulphonic acid (TNBS)‐induced colitis, a model for T helper 1 (Th1) type disease, was investigated in BALB/c mice. The AIF‐1 expression was significantly increased in the colitis lesion compared to that in the normal colon. We then prepared AIF‐1 transgenic mice (Tgm) with the BALB/c background that express high levels of AIF‐1 in lymphoid tissues and the colon. When AIF‐1 Tgm were administrated TNBS, the TNBS‐induced colitis was ameliorated compared with that in non‐transgenic littermates. The amelioration of colitis was associated with the low expression of interleukin‐1β in the colon. The present findings suggest that AIF‐1 regulates Th1‐type inflammatory responses.