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X‐chromosome‐linked immune‐deficient mice have B‐1b cells
Author(s) -
Riggs J.,
Howell K.,
Matechin B.,
Matlack R.,
Pennello A.,
Chiasson R.
Publication year - 2003
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.2003.01624.x
Subject(s) - bruton's tyrosine kinase , cd23 , cd5 , immune system , b cell , peritoneal cavity , biology , spleen , immunology , phenotype , b 1 cell , lymphocyte , immunophenotyping , microbiology and biotechnology , flow cytometry , genetics , antibody , t cell , immunoglobulin e , gene , tyrosine kinase , antigen presenting cell , receptor , anatomy
Summary The B lymphocyte subsets of X‐chromosome‐linked immune‐deficient (XID) mice were examined by flow cytometric analyses of spleen and peritoneal cells. As shown in prior studies, young adult XID mice had reduced representation of the CD5 + (B‐1a) subset in their peritoneal cavity. However, the CD11b + (B‐1b) B‐cell subset was present and exhibited the IgM hi CD45 lo CD23 − phenotype characteristic of most B‐1 cells. Although present at a lower frequency than that found in their normal counterparts, B‐1b cells were evident in CBA/N and (XD2J)F 1 male mice. With increasing age, B‐1b cell number increased and in the oldest XID mice were present as B‐cell chronic lymphocytic leukaemia. These results show that XID mice do have B‐1 cells, particularly the B‐1b subset.