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Chronic restraint stress induces severe disruption of the T‐cell specific response to tetanus toxin vaccine
Author(s) -
Tournier J. N.,
Mathieu J.,
Mailfert Y.,
Multon E.,
Drouet C.,
Jouan A.,
Drouet E.
Publication year - 2001
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.2001.01152.x
Subject(s) - immunology , immune system , tetanus , antigen , antibody , stimulation , isotype , secretion , humoral immunity , spleen , biology , toxin , cytokine , medicine , vaccination , monoclonal antibody , endocrinology , microbiology and biotechnology
Summary Chronic stress is known to induce immunological disorders. In the present study we examined the consequences of chronic restraint stress on the immune response to tetanus toxin in mice. We investigated the repartition of subsets of lymphoid cells in blood and spleen, the functional ability of lymphocytes to proliferate and to produce cytokines, and antibody titres against tetanus toxin following stress. We report discordance of the stimulation index of lymphocytes in the restraint group: the proliferating rate severely decreased following stimulation with a relevant antigen, whereas it increased with mitogen. Thus, we report a decrease in cytokine production with relevant antigen (interferon‐γ and interleukin‐10), without a T helper type 1 and 2 secretion imbalance. Moreover, we observed an alteration in the humoral response, including a delay in isotype maturation and an immunoglobulin G1/G2a imbalance.