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Immunostimulatory bacterial DNA sequences activate dendritic cells and promote priming and differentiation of CD8 + T cells
Author(s) -
Tascon R. E.,
Ragno S.,
Lowrie D. B.,
Colston M. J.
Publication year - 2000
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.2000.00941.x
Subject(s) - priming (agriculture) , cytotoxic t cell , biology , microbiology and biotechnology , antigen presenting cell , dendritic cell , cd8 , cd40 , antigen , immunology , in vitro , biochemistry , botany , germination
Summary CD8 + T lymphocytes producing high levels of interferon‐γ (IFN‐γ) and expressing antigen specific cytotoxic activity are effectively induced after plasmid DNA vaccination and mediate protection against several intracellular micro‐organisms. Recent evidence suggests that the priming of CD8 + T‐cell responses following DNA injection involves antigen presentation mediated by dendritic cells. Here, we show that bacterial DNA and synthetic oligonucleotides containing dinucleotide (CpG) motifs activate cytokine expression in dendritic cells and modulate in vivo CD8 + T‐cell priming and differentiation.