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Activation, survival and apoptosis of CD45RO + and CD45RO − T cells of human immunodeficiency virus‐infected individuals: effects of interleukin‐15 and comparison with interleukin‐2
Author(s) -
Honami Naora,
MarieLise Gougeon
Publication year - 1999
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.1999.00807.x
Subject(s) - biology , interleukin 15 , cd8 , apoptosis , interleukin 2 , interleukin 3 , t cell , cytotoxic t cell , population , immunology , il 2 receptor , interleukin 21 , interleukin , cytokine , immune system , in vitro , medicine , biochemistry , environmental health
HIV infection is associated with increased representation of T cells bearing an activated, memory (CD45RO + ) phenotype. Although administration of antiretroviral agents and interleukin‐2 (IL‐2) augment depleted CD4 + T‐cell numbers, such therapies have been preferentially beneficial for CD45RO + T cells. Interleukin‐15 (IL‐15) exhibits many biological activities in common with IL‐2, including promoting T‐cell survival and proliferation. The present study found that these two cytokines differed in their ability to induce proliferation, enhance survival, and control apoptosis of CD45RO + and CD45RO − T‐cell populations of human immunodeficiency‐ (HIV) infected individuals. When used at equivalent concentrations in vitro , IL‐15 was more potent than IL‐2 in activating and stimulating proliferation of CD4 + CD45RO + , CD8 + CD45RO + and CD8 + CD45RO − cells, but failed to be more effective than IL‐2 in reducing apoptosis. Poor activation of CD4 + CD45RO − cells by IL‐15 and to IL‐2 appeared to be attributable to low expression of the β receptor chain utilized by both cytokines. However, IL‐15 was more effective than IL‐2 in enhancing survival of the CD4 + CD45RO − population, suggesting a greater protective effect of IL‐15 for naive CD4 + T cells, which are preferentially lost in HIV‐infected individuals.