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Cross‐talk between γδ T lymphocytes and immune cells in humoral response
Author(s) -
Szczepanik,
Bernadeta Nowak,
Askenase,
Ptak
Publication year - 1998
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.1998.00642.x
Subject(s) - biology , immune system , gamma delta t cell , t cell , microbiology and biotechnology , cd40 , immunology , b 1 cell , il 2 receptor , antigen presenting cell , interleukin 21 , cytotoxic t cell , t cell receptor , in vitro , genetics
The role of γδ T cells in immunoregulation is largely unknown. In the current study we noted that γδ T cells play a positive role in the humoral response. These positively acting γδ T cells are required for the successful adoptive cell transfer of the humoral response, as well as for in vitro generation of plaque‐forming cells (PFC). The presented results show that γδ T cells cause an increase in interleukin‐10 (IL‐10) production, which partly elucidates the mechanism of action of these cells. However, experiments with cell culture inserts strongly suggest that direct cell–cell contact between immune and γδ H‐2‐compatible regulatory T cells is critical to the exertion of the positive immunoregulatory function of γδ cells. The mechanism of cross‐talk between these two cell populations is still not clear but we regard as most likely that the positively acting γδ T cells may interact with a complex of heat‐shock protein–non‐polymorphic MHC (IB) on the surface of T helper type 2 and/or B cells. This could provide, by direct cell–cell contact, the cognate recognition between γδ T‐cell receptors and heat‐shock protein–MHC that leads to positive internal signalling in the immune cells.