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Modulation of Ly49A receptors on mature cells to changes in major histocompatibility complex class I molecules
Author(s) -
Nelson K.S. Khoo,
Linda Fahlén,
Charles L. Sentman
Publication year - 1998
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.1998.00577.x
Subject(s) - major histocompatibility complex , mhc class i , microbiology and biotechnology , receptor , cd8 , biology , cd1 , in vivo , immunology , immune system , natural killer t cell , genetics
The expression of murine Ly49 receptors on natural killer (NK) cells and NK1.1 + T cells is believed to prevent these cells from responding against normal self‐tissues. In this report we investigated whether the expression level of Ly49A was fixed on mature cells or if it could be adapted as the major histocompatibility complex (MHC) class I environment changed in vivo . By transferring peripheral T cells from Ly49A transgenic mice into BALB/c nude/nude and B6 nude/nude mice, we demonstrated that mature cells modulate their Ly49A receptor expression relative to the in vivo MHC class I environment. These results indicated that the expression of the inhibitory Ly49A receptor is not permanently fixed during a maturation and/or education process but rather is adapted to MHC class I changes on the surrounding cells.