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Increased serum IgG1 levels and reduced numbers of B‐1 B cells in DBA/2J mice
Author(s) -
TOCCE* K.,
MASTERS† G.,
RAGO‡ C.,
PRIOR§ L.,
SUPPIAH¶ K.,
GLYSINGJENSEN** T.,
LEARY S.,
RIGGS J.
Publication year - 1998
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.1998.00531.x
Subject(s) - superantigen , b cell , biology , spleen , immunology , bone marrow , lymphocyte , naive b cell , microbiology and biotechnology , antigen , b 1 cell , t cell , antibody , antigen presenting cell , immune system
B‐cell heterogeneity studies have historically focused upon BALB/c mice and their derivatives. In contrast, the B cells of DBA/2J mice, a prototype strain for the study of the endogenous minor lymphocyte stimulatory (Mls) viral superantigen Mls‐1 a , have not been extensively investigated. DBA/2J B cells, by functioning as Mls‐1 a antigen‐presenting cells, influence their own differentiation and diversity by inducing the proliferation and differentiation of specific CD4 T‐cell subsets. In this report, the B cells of DBA/2J and BALB/c mice were compared for their ability to restore B‐cell function in severe combined immunodeficient (SCID) recipients. Although spleen and bone marrow cells from these strains exhibited similar restoration of serum IgM production, the transfer of DBA/2J B cells into SCID mice led to greater IgG1 production. The peritoneal cells of DBA/2J mice consisted of a lower percentage of B‐1 B cells and were less capable of restoring B‐cell function after transfer into SCID recipients. These differences are discussed with respect to the possible role of viral superantigens in influencing B‐lymphocyte diversity.