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Circulating immune complexes from HIV‐1 + patients induces apoptosis on‘qc normal lymphocytes
Author(s) -
ACEITUNO E.,
CASTAÑÓN S.,
JIMÉNEZ C.,
SUBIRÁ D.,
DE GÓRGOLAS M.,
FERNÁNDEZGUERRERO M.,
ORTÍZ F.,
GARCÍA R.
Publication year - 1997
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.1997.00361.x
Subject(s) - immune system , apoptosis , human immunodeficiency virus (hiv) , immunology , chemistry , microbiology and biotechnology , medicine , biology , biochemistry
Isolated immune complexes from sera of 49 out of 67 human immunodeficiency virus‐1‐positive (HIV‐1 + ) patients (CIC–HIV + ), composed of anti‐HIV–HIV‐Ag, could induce apoptosis on normal phytohaemagglutinin (PHA)‐activated lymphocytes. DNA degradation was detected by propidium iodide staining. This activity is directed against CD4 + lymphocytes as demonstrated by double binding of CIC–HIV + and anti‐CD4 on apoptotic cells. Expression of Fas antigen is prior to apoptotic phenomena. CIC–HIV + apoptosis inducers belong mainly to asymptomatic HIV‐infected patients, indicating that immune complexes from these patients can destroy CD4 + lymphocytes.