Premium
Expression of L‐selectin (CD62L) discriminates Th1‐ and Th2‐like cytokine‐producing memory CD4 + T cells
Author(s) -
KANEGANE H.,
KASAHARA Y.,
NIIDA Y.,
YACHIE A.,
SUGII S.,
TAKATSU K.,
TANIGUCHI N.,
MIYAWAKI T.
Publication year - 1996
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1046/j.1365-2567.1996.446530.x
Subject(s) - l selectin , interleukin 21 , biology , cytokine , homing (biology) , immunology , natural killer t cell , t cell , memory t cell , interleukin 4 , il 2 receptor , microbiology and biotechnology , immune system , cell adhesion molecule , ecology
Human memory (CD45RO + ) CD4 + T cells can be distinguished into two subpopulations on the basis of expression of the lymph node homing receptor, L‐selectin (CD62L). In a prior study we showed that human L‐selectin‐positive memory T‐helper (Th) cells promote the maturation of IgG‐ and IgA‐producing cells by naive B cells. To further elucidate the contribution of memory CD4 + T cells to B‐cell differentiation, human memory CD4 + T cells with or without L‐selectin expression were evaluated for production of cytokines that participate in regulation of immunoglobulin production. It was found that L‐selectin‐positive human memory CD4 + T cells produce mainly interleukin (IL)‐4 and IL‐5, whereas L‐selectin‐negative CD4 + T cells produce mainly interferon‐γ (IFN‐γ). This profile of cytokine expression coincides with the profile that distinguishes Th1 and Th2 subsets. In contrast to the murine system, IL‐10 production was similarly contributed by human L‐selectin‐positive and ‐negative memory CD4 + T‐cell subpopulations. These results suggest that the human L‐selectin‐negative and ‐positive subpopulations of human memory CD4 + T cells contain Th1‐like and Th2‐like cytokine‐producing cells, respectively.