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Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts
Author(s) -
De Silva M V C,
Raby N,
Reid R
Publication year - 2003
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2003.01666.x
Subject(s) - curettage , medicine , aneurysmal bone cyst , osteoid , confidence interval , odds ratio , hazard ratio , histopathology , surgery , radiology , pathology , lesion
Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts. Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively ( P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis‐like fibromyxoid areas [ P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts ( P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features. Conclusions: Aneurysmal bone cysts with nodular fasciitis‐like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow‐up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur.