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Ossifying fibromyxoid tumour of soft parts, with focus on unusual clinicopathological features
Author(s) -
Holck S,
Pedersen J G,
Ackermann T,
Daugaard S
Publication year - 2003
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2003.01623.x
Subject(s) - ossification , pathology , axilla , immunohistochemistry , soft tissue , anatomy , medicine , lesion , head and neck , cancer , surgery , breast cancer
Aims: Ossifying fibromyxoid tumour is a rare lesion that generally occurs in the soft tissues of proximal limbs/girdle, or head and neck. Histologically, it usually consists of bland, mitotically inactive, S100+ cells in a fibromyxoid matrix with a characteristic peripheral ossification. However, we present two cases that deviated from this pattern. Material and methods: One tumour, which was removed from the axilla of a 55‐year‐old female, was unusual in its large size (120 mm in diameter) and in its restriction of bone formation to its central zones. The other tumour, which occurred in a 62‐year‐old female, was remarkable in its acral location on the hand and high mitotic activity (four mitoses per high‐power field). These features caused concern and follow‐up of the patients was recommended. So far there have been no recurrences (25 and 18 months after surgery, respectively). An additional previously undescribed feature was the presence of fibronexus‐like structures by electron microscopy in the second case. However, a myofibroblastic phenotype was not supported by the immunohistochemical findings. Conclusion: Though a distinct entity, ossifying fibromyxoid tumour may exhibit a wider clinicopathological spectrum than generally recognized.