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Cyclin E immunoexpression in gastric cancer does not correlate with clinicopathological parameters
Author(s) -
Chetty R,
Sitti C W
Publication year - 2003
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2003.01519.x
Subject(s) - immunohistochemistry , immunostaining , lymph node , pathology , cyclin d1 , cancer , medicine , staining , cyclin a , cyclin , biology , cell cycle
Aims: To ascertain whether cyclin E immunoexpression relates to clinicopathological characteristics of gastric cancer and is of possible routine use. Methods and results: One hundred and twenty‐four gastrectomy specimens were assessed for age, gender, histological subtype, lymph node status and Helicobacter pylori infection. Immunohistochemistry using a commercially available antibody to cyclin E was then applied to the cases. The immunohistochemical staining was correlated with clinicopathological features. Fifty‐three of 124 cases were cyclin E‐positive, with 28 of these cases showing >50% of the tumour cells staining. However, no statistical significance was obtained between cyclin E immunostaining and any clinicopathological parameter, especially lymph node spread. Conclusions: We have not demonstrated any significant relationship between cyclin E immunopositivity and any of the usual clinicopathological parameters (especially lymph node involvement) and therefore cyclin E immunohistochemistry alone does not appear to have a role in the assessment of gastric cancer currently.