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Clear cell sarcoma of the stomach
Author(s) -
Pauwels P,
DebiecRychter M,
Sciot R,
Vlasveld T,
Den Butter B,
Hagemeijer A,
Hogendoorn P C W
Publication year - 2002
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2002.01509.x
Subject(s) - sarcoma , clear cell sarcoma , pathology , melanoma , stomach , immunohistochemistry , fluorescence in situ hybridization , medicine , biology , cancer research , biochemistry , chromosome , gene
Aim: Clear cell sarcoma is a high‐grade sarcoma with morphological features resembling malignant melanoma. This tumour is reported to display a characteristic distribution pattern nearly always involving the extremities. We report the first case of clear cell sarcoma of the stomach. Methods and results: A 30‐year‐old male developed a huge tumour of the stomach, which at first glance could be considered as a poorly differentiated carcinoma. Immunohistochemical and ultrastructural examinations were consistent with a diagnosis of metastatic melanoma. However, cytogenetic examination revealed a t(12;22) translocation, specific for clear cell sarcoma. This was confirmed by fluorescence in‐situ hybridization. Conclusion: Making a reliable diagnosis of clear cell sarcoma of the stomach requires cytogenetic or molecular diagnostic investigations, particularly to rule out metastatic melanoma. This diagnosis avoids an unnecessary search for a primary melanoma.