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Comparative evaluation of the prognostic value of MUC1, MUC2, sialyl‐Lewis a and sialyl‐Lewis x antigens in colorectal adenocarcinoma
Author(s) -
Baldus S E,
Mönig S P,
Hanisch FG,
Zirbes T K,
Flucke U,
Oelert S,
Zilkens G,
Madejczik B,
Thiele J,
Schneider P M,
Hölscher A H,
Dienes H P
Publication year - 2002
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2002.01389.x
Subject(s) - muc1 , sialyl lewis x , adenocarcinoma , antigen , immunostaining , pathology , immunohistochemistry , colorectal cancer , mucin , medicine , univariate analysis , oncology , cancer , immunology , multivariate analysis , selectin , inflammation
Comparative evaluation of the prognostic value of MUC1, MUC2, sialyl‐Lewis a and sialyl‐Lewis x antigens in colorectal adenocarcinomaAims : The significance of MUC1, MUC2 and sialylated Lewis blood group antigens as prognostic markers in colorectal adenocarcinoma was investigated in a large series of patients because previous investigations revealed inconsistent results due to unrelated tumour samples from different patient groups and methodological differences. Methods and results : Tissues from 243 patients with colorectal adenocarcinoma were stained immunohistochemically. MUC1 showed a strong immunoreactivity (in more than 35% of the tumour area) in 32.5%, MUC2 in 51.0%, sialyl‐Lewis x in 67.9% and sialyl‐Lewis a in 73.7% of the cases, respectively. MUC1 immunoreactivity displayed a significant correlation with tumour progression as reflected by advancing pTNM staging and poor differentiation. MUC2 expression was significantly stronger in mucinous adenocarcinomas. Sialyl‐Lewis x immunostaining correlated with the extent of lymph node metastasis as well as low cytological differentiation. According to univariate and multivariate analysis ( P < 0.0001) only MUC1 reactivity represented a marker of worse survival probability, opposed to the sialylated Lewis antigens that did not exert a predictive value. Conclusions : According to our data, MUC1 and sialyl‐Lewis x immunoreactivity exhibit statistically significant correlations with established markers of tumour progression. However, only MUC1 presents as an independent prognostic factor of colorectal adenocarcinoma.