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Extranodal mantle cell lymphoma mimicking marginal zone cell lymphoma
Author(s) -
Anagnostopoulos I,
Foss HD,
Hummel M,
Trenn G,
Stein H
Publication year - 2001
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2001.01303.x
Subject(s) - mantle cell lymphoma , marginal zone , mantle zone , immunophenotyping , lymphoma , cd5 , cyclin d1 , pathology , splenic marginal zone lymphoma , marginal zone b cell lymphoma , biology , blastoid , gene rearrangement , b cell , antigen , antibody , medicine , immunology , cell , cell cycle , gene , germinal center , biochemistry , genetics
Extranodal mantle cell lymphoma mimicking marginal zone cell lymphomaAim : We report a case of mantle cell lymphoma masquerading as a marginal zone cell lymphoma. Methods and results : In the initial manifestation in the palatine tonsils, the neoplastic cells were found to grow exclusively within the marginal zones of secondary follicles which showed a preserved mantle zone. The few immunostains performed showed a B‐cell phenotype including an immunoglobulin light chain restriction. The extranodal manifestation, the growth pattern, and the immunophenotype led to the diagnosis of an extranodal marginal zone B‐cell non‐Hodgkin’s lymphoma (NHL). The specimen from the relapse occurring 8 months later exhibited diffuse monomorphous cells co‐expressing B‐cell antigens and CD5, CD43 and cyclin D1, leading to the diagnosis of mantle cell lymphoma. Re‐investigation of the initial biopsy revealed that the neoplastic cells within the marginal zones had a mantle cell lymphoma immunophenotype expressing cyclin D1, the immunoglobulin heavy chains IgD and IgM and partly CD5. Both lesions harboured identical clonal immunoglobulin gene rearrangements proving that they represented different manifestations of the same lymphoma. Conclusion : This case emphasizes the importance of broad immunohistological investigation of B‐cell NHLs involving the marginal zone.