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Cutaneous sclerosing Pacinian‐like perineurioma
Author(s) -
Burgues O,
Monteagudo C,
Noguera R,
Revert A,
Molina I,
LlombartBosch A
Publication year - 2001
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2001.01251.x
Subject(s) - pathology , fluorescence in situ hybridization , immunohistochemistry , anatomy , lesion , biology , medicine , chromosome , gene , biochemistry
Cutaneous sclerosing Pacinian‐like perineuriomaAims : The term perineurioma has been used to designate a variety of clinically and histologically different proliferations of perineurial cells based on immunohistochemical and/or ultrastructural characterization. There are two different groups of neoplasms derived from perineurial cells: extraneural or soft tissue perineuriomas, and intraneural perineuriomas. Recently, a sclerosing variant of cutaneous perineurioma has been described. Methods and results : We report a case of a cutaneous form of perineurioma, combining features of the intraneural and sclerosing varieties, as well as showing a Pacinian pattern of growth. In order to assess the neoplastic nature of the lesion, we performed fluorescence in‐situ hybridization (FISH) analysis using a probe which maps to the chromosome band 22q11 and 22q13, allowing us to show deletion or loss of one chromosome 22 in the tumour cells. Conclusions : This case may be considered a new variant of perineurioma with Pacinian‐like features, for which we propose the designation ‘sclerosing Pacinian‐like perineurioma’.