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Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature
Author(s) -
Menasce L P,
Shanks J H,
Banerjee S S,
Harris M
Publication year - 2001
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2001.01210.x
Subject(s) - lamina propria , follicular hyperplasia , pathology , germinal center , follicular lymphoma , lymphoid hyperplasia , hard palate , lymphoma , follicular phase , hyperplasia , medicine , pseudolymphoma , immunohistochemistry , biology , antibody , epithelium , immunology , b cell , surgery
Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literatureAims : To bring to wider attention this uncommon, poorly understood entity which may closely resemble, clinically and morphologically, follicular lymphoma. Methods and results : We report three cases of follicular lymphoid hyperplasia of the hard palate and oral mucosa which caused diagnostic difficulties for the referring pathologists. The clinicopathological features are described and integrated into a review of the 16 previously recorded cases. The condition most commonly presents as a slowly growing mass situated in the posterior hard palate but may present with multicentric oral lesions and lymphadenopathy. Morphologically, it is characterized by a dense follicular lymphoid infiltrate within the lamina propria which may show the classical features of benign reactive hyperplasia, but not uncommonly, indistinct germinal centres, ill‐defined mantles and a lack of tingible‐body macrophages are features which may lead to an erroneous diagnosis of follicular lymphoma. Conclusions : Follicular lymphoid hyperplasia of the palate is a poorly recognized entity which is frequently confused with follicular lymphoma. Awareness of the entity combined with the use of immunohistochemistry for immunoglobulin light chains and bcl‐2 protein allows a correct diagnosis to be made avoiding extensive investigation and aggressive treatment to the patient.