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Giant cell arteritis localized to the colon associated with Crohn's disease
Author(s) -
Colombat M,
Imbert A,
Bruneval P,
Chatelain D,
Gontier MF
Publication year - 2001
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2001.01063.x
Subject(s) - giant cell arteritis , medicine , vasculitis , giant cell , pathology , internal elastic lamina , arteritis , epithelioid cell , crohn's disease , disease , artery , immunohistochemistry
Intestinal vasculitis is uncommon and usually accompanies systemic vasculitis. Although intestinal vascular changes including vasculitis have been studied intensively, and are found regularly in Crohn's disease, giant cell arteritis is distinctly unusual. We describe a case of giant cell arteritis localized to the colon of an 18‐year‐old girl suffering from Crohn's disease. After three years of medical treatment, the patient underwent a proctocolectomy. The medium‐sized arteries of the mesocolon demonstrated striking changes characterized by intimal fibrous thickening and an inflammatory infiltrate with giant cells, most predominant at the intima–media junction. Epithelioid cells and sarcoid‐like granulomas were not observed. The internal elastic lamina was fragmented. Neither clinical symptoms nor laboratory findings showed evidence of systemic vasculitis. Neither the chest CT scan nor the echo‐Doppler of the temporal arteries, supra‐aortic and abdominal vessels revealed any abnormality. This case illustrates an extremely rare feature in the spectrum of vascular lesions in Crohn's disease which have to be differentiated from temporal and Takayasu's arteritis.