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Neutrophil and endothelial cell activation in the vasa vasorum in vasculo‐Behçet disease
Author(s) -
Mikiko Kobayashi,
Masafumi Ito,
Atsushi Nakagawa,
Masayuki Matsushita,
Naomichi Nishikimi,
Tsunehisa Sakurai,
Yuji Nimura
Publication year - 2000
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2000.00859.x
Subject(s) - vasa vasorum , arteritis , medicine , pathology , vasculitis , inflammation , immunology , disease
Aim The aim of this study was to analyse the immunopathological mechanisms of vasculo‐Behçet disease, which were also compared to cases of Takayasu's arteritis and inflammatory aneurysm to evaluate differences in inflammatory mechanisms. Method and results We reviewed six cases of vasculo‐Behçet disease, four of Takayasu's arteritis and seven inflammatory aneurysms which underwent surgical repair. Immunohistochemical studies were performed on paraffin‐embedded tissue using a labelled streptavidin–biotin method, as was in‐situ hybridization for Epstein–Barr virus. Microscopically, neutrophils and lymphocytes accumulated around the vasa vasorum. Neutrophils were prominent as compared to Takayasu's arteritis and inflammatory aneurysm. Elastic fibres were not severely destroyed. Endothelial cells (ECs) of most vasa vasorum expressed HLA‐DR. The number of vasa vasorum around which inflammatory infiltrating cells were observed in vasculo‐Behçet disease was significantly greater than in inflammatory aneurysms and Takayasu's arteritis ( P < 0.001). The cytokines IL‐1α, TNF‐β and IFN‐γ were expressed in neutrophils and lymphocytes which were distributed around vasa vasorum, as well as neutrophils adherent to HLA‐DR positive ECs. Conclusion Our results suggest that vasculo‐Behçet disease should be classified as a neutrophilic vasculitis targeting the vasa vasorum. Aneurysm formation may be related to degeneration of arterial wall caused by inflammation of the vasa vasorum.