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CD101 expression by Langerhans cell histiocytosis cells
Author(s) -
Anne Bouloc,
Boulland Ml,
Frédéric Geissmann,
Sylvie Fraïtag,
P. Andry,
D. Teillac,
Armand Bensussan,
J Revuz,
Laurence Boumsell,
Janine Wechsler,
M. Bagot
Publication year - 2000
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2000.00827.x
Subject(s) - langerhans cell histiocytosis , immunohistochemistry , histiocytosis , antibody , cell , pathology , medicine , protein expression , disease , immunology , biology , gene , biochemistry
Aims Our objective was to study the expression of a recently identified cell surface molecule, CD101 and in Langerhans cell histiocytosis (LCH) patients as CD101 has been shown to be present on dendritic cells. We wanted to determine if CD101 expression could be helpful for the diagnosis of LCH in conjunction with other markers (CD1a, S100 protein), and could be predictive of the evolution and dissemination of the disease. Methods and results The expression of CD101 was studied by immunohistochemical technique in 11 cases of Langerhans cell histiocytosis on frozen sections. The expression of CD101 was positive in nine cases, high in six cases and low in three cases. There was no expression in the other two cases. No correlation with the evolution, the localization or the dissemination of the disease could be evidenced. Conclusions CD101 is a new phenotypic marker that might be useful in combination with other markers for the diagnosis of LCH. However, as the anti‐CD101 antibody works only in frozen sections, its value is limited compared to anti‐CD1a antibody.