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MIB‐1 proliferation index correlates with survival in pleural malignant mesothelioma
Author(s) -
Comin,
Roberto Anichini,
Boddi,
Novelli,
. Dini
Publication year - 2000
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.2000.00793.x
Subject(s) - mesothelioma , immunostaining , immunohistochemistry , pathology , medicine , oncology , monoclonal antibody , survival analysis , antibody , immunology
Aims The purpose of this study was to establish whether the cell proliferation index assessed by the monoclonal antibody MIB‐1 would correlate with survival in pleural malignant mesothelioma. Methods and results We studied a series of seven long‐term survivors with pleural malignant mesothelioma and a group of control cases with short‐term survival. All cases showed MIB‐1 positive cells, and labelling indices were expressed as percentage of cells with positive nuclear immunostaining by randomly counting 1000 tumour cells. A statistically significant difference was found between MIB‐1 values in the long‐term survival group and the control cases with short‐term survival. Conclusions Our results indicate that the differences in biological behaviour of malignant mesothelioma in long‐term and short‐term survivors may be explained in part by differences in tumour growth fraction and that proliferation index could represent an important prognostic parameter for this tumour.