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Sinus histiocytosis with massive lymphadenopathy: evidence for its relationship to macrophages and for a cytokine‐related disorder
Author(s) -
Peter Middel,
Bernhard Hemmerlein,
Afshin Fayyazi,
U Kaboth,
Radzun Hj
Publication year - 1999
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1999.00746.x
Subject(s) - histiocyte , macrophage , immunology , monocyte , antigen , histiocytosis , antigen presenting cell , birbeck granules , pathology , immune system , biology , dendritic cell , t cell , medicine , disease , langerhans cell , biochemistry , in vitro
Aims Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai–Dorfman disease is a rare histiocytic disorder of unknown origin. Immunophenotypically the histiocytes of SHML express intensively the S100 protein and in addition a panel of macrophage‐associated antigens. Their exact relationship to either monocytes/macrophages or immune accessory dendritic cells is, however, still controversial. Methods and results In this report recurrent nodal and extranodal manifestations of SHML of a 70‐year‐old patient were analysed by differential phenotyping using a panel of monoclonal and polyclonal antibodies to macrophage and immune accessory dendritic cell related antigens and by applying nonradioactive in‐situ hybridization. Conclusions We conclude that stimulation of monocytes/macrophages via macrophage colony stimulating factor (M‐CSF) leading to immune suppressive macrophages represents a main mechanism for the pathogenesis of SHML. The study further provides evidence for the monocyte/macrophage but not dendritic cell differentiation of SHML histiocytes.