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Blastic transformation of mantle cell lymphoma: genetic evidence for a clonal link between the two stages of the tumour
Author(s) -
Terézia László,
András Matolcsy
Publication year - 1999
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1999.00745.x
Subject(s) - mantle cell lymphoma , clone (java method) , biology , lymphoma , gene , polymerase chain reaction , transformation (genetics) , immunoglobulin heavy chain , microbiology and biotechnology , nucleic acid sequence , genetics , cancer research , immunology
Aims The blastic variant of mantle cell lymphoma (MCL‐BV) may develop through histological transformation of mantle cell lymphoma (MCL). However, the clonal link between the tumour cells of MCL and transformed MCL‐BV has not been established at the genetic level. To investigate this link longitudinal molecular genetic studies have been performed in two cases of MCL that showed morphological transformation to MCL‐BV. Methods and results Polymerase chain reaction (PCR) and nucleotide sequence analyses of the complementary determining region 3 (CDR) of the immunoglobulin ( Ig ) heavy chain ( H ) gene were performed to identify clone‐specific rearrangements. In both cases, nucleotide sequence analysis revealed common clone‐specific IgH gene rearrangements in MCL and subsequent MCL‐BV. Conclusions These results provide genetic evidence for the common clonal origin of MCL and subsequently developed MCL‐BV.