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Immunostaining for cyclin D1 and the diagnosis of mantle cell lymphoma: is there a reliable method?
Author(s) -
John K. Chan,
KD Miller,
Philippa Munson,
Peter G. Isaacson
Publication year - 1999
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1999.00662.x
Subject(s) - mantle cell lymphoma , cyclin d1 , immunostaining , lymphoma , medicine , pathology , diagnostic accuracy , radiology , immunohistochemistry , cell cycle , cancer
Immunostaining for cyclin D1 has become essential for the reliable diagnosis of mantle cell lymphoma (MCL). MCL is associated with a poor prognosis and its distinction from other small B‐cell lymphomas is clinically important. However, many diagnostic laboratories report problems in finding a reliable method. The following articles by Chan and by Miller, Munson & Isaacson discuss the common problems and describe successful methods with advice on diagnostic interpretation.