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Haemophilic arthropathy resembles degenerative rather than inflammatory joint disease
Author(s) -
G. Roosendaal,
A. C. van Rinsum,
M. E. Vianen,
H. M. Van Den Berg,
Floris P. J. G. Lafeber,
J. W. J. Bijlsma
Publication year - 1999
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1999.00608.x
Subject(s) - arthropathy , medicine , haematoxylin , pathology , inflammation , cartilage , osteoarthritis , arthritis , degenerative disease , rheumatoid arthritis , spondylitis , glycosaminoglycan , joint disease , immunology , staining , disease , ankylosing spondylitis , anatomy , alternative medicine
Aims To investigate the pathogenetic mechanisms of haemophilic arthropathy (HA) by comparing end‐stage arthropathy with osteoarthritis (OA; a degenerative joint disorder) and rheumatoid arthritis (RA; an inflammation‐mediated joint disease). Methods and results Cartilage and synovium from patients with HA ( n = 10), RA ( n = 8), OA ( n = 14) and normal control subjects ( n = 6) were examined morphologically, biochemically and histochemically. Cartilage in HA exhibited characteristics of degenerative joint disease (OA), as evidenced by morphological, histochemical (Safranin‐O fast green‐iron haematoxylin, Mankin grade) and biochemical (proteoglycan synthesis, glycosaminoglycan content and DNA content) changes, whereas synovium in HA showed characteristics of inflammation‐mediated joint disease (RA), as evidenced by histochemical (inflammation, haematoxylin and eosin (H&E) and iron deposition, Perls' blue) and biochemical changes (interleukin (IL)‐1, IL‐6, tumour necrosis factor (TNF)α and catabolic properties). Conclusion Haemophilic arthropathy shows characteristics of both inflammatory and degenerative joint disease. On the basis of these results and published information, it appears that degenerative cartilage changes have a dominant role in HA and are augmented by relatively mild inflammation of the synovium.