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Peliosis of the spleen: an immune‐complex disease?
Author(s) -
Gugger M,
Gebbers JO
Publication year - 1998
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1998.00493.x
Subject(s) - spleen , pathology , pathogenesis , reticular connective tissue , immunohistochemistry , immune system , lesion , medicine , immunology
Aims To determine the pathogenesis of splenic peliosis by further morphological and immunohistochemical examination. Methods and results Histological, electron microscopic and immunohistochemical examination revealed evidence for an inflammatory genesis of splenic peliosis with destruction of reticular fibres and local deposits of IgG and activated complement C3. Conclusion Our findings indicate that the peliotic lesion in the spleen may be mediated by immune‐complex deposits.