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Differentiation of desquamative interstitial pneumonia (DIP) from pulmonary adenocarcinoma by immunocytochemistry
Author(s) -
Mutton A E,
Hasleton P S,
Curry A,
Bishop P W,
Egan J,
Carroll K B,
Hanley S
Publication year - 1998
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1998.00463.x
Subject(s) - cytokeratin , pathology , adenocarcinoma , immunohistochemistry , medicine , pulmonary adenocarcinoma , pneumonia , cancer
Aim After a misdiagnosis of pulmonary adenocarcinoma as desquamative interstitial pneumonia (DIP), we investigated whether immunohistochemical markers could differentiate these conditions. Methods and results Three cases of DIP and one pulmonary adenocarcinoma masquerading as DIP were studied by light and electron microscopy. All cases were mucin‐negative. The cases of DIP were CD68 positive but cytokeratin‐negative. The adenocarcinoma was cytokeratin‐positive (AE1/3 and CAM5.2), as well as showing some CD68‐positive cells. Markers for carcinoma (CEA, Ber‐EP4, and Leu M1) were negative in all cases. Ultrastructurally the adenocarcinoma appeared to be derived from Type II pneumocytes. Conclusion Before a diagnosis of DIP is made, cytokeratin markers should be used.