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Massive lymphocytic infiltration of uterine leiomyomas associated with GnRH agonist treatment
Author(s) -
Bardsley V,
Cooper P,
Peat D S
Publication year - 1998
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1998.00451.x
Subject(s) - haematoxylin , cd20 , uterine leiomyoma , infiltration (hvac) , pathology , agonist , leiomyoma , medicine , immunohistochemistry , lymphocytic infiltration , cd3 , uterus , h&e stain , endocrinology , receptor , cd8 , immunology , antigen , physics , thermodynamics
Aims To report two unusual cases of massive lymphocytic infiltration of uterine leiomyomas, following GnRH agonist treatment. Previous reports have described a variety of alterations in leiomyoma histology following such therapy. Methods and results These cases were studied using haematoxylin and eosin stains, and immunohistochemistry for B and T‐cell markers (CD20/CD79a and CD3/UCHL‐1) was performed. Leiomyomas were heavily infiltrated predominantly by mature lymphocytes of T‐cell phenotype. Associated myocyte degenerative changes were present. Conclusion Massive lymphocytic infiltration of leiomyomas may occur as a result of GnRH agonist treatment, although the mechanism is unclear.