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Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge
Author(s) -
Mel Β. Feany,
Douglas C. Anthony,
Christopher D.�M. Fletcher
Publication year - 1998
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1998.00419.x
Subject(s) - schwannoma , neurofibromatosis , neurofibroma , pathology , lesion , plexiform neurofibroma , nerve sheath tumor , immunohistochemistry , biology , medicine , anatomy
Aims To characterize and delineate a subset of rare nerve sheath tumours showing hybrid features of neurofibroma and schwannoma. Methods and results Nine lesions were identified in the authors' files showing predominant features of neurofibroma with distinct, often nodular regions of classical schwannomatous differentiation. Most patients were adults, eight out of nine were male. Of the nine lesions, two were dermal, two were subcutaneous and five were subfascial. Five lesions had a plexiform architecture and one patient had overt neurofibromatosis. One out of six patients with follow‐up developed local recurrence. Schwannoma‐like regions displayed strong S100 staining, in contrast to more varied and limited S100 reactivity in neurofibromatous areas. The Antoni A areas could be quite cellular with high MIB‐1 proliferation indices. No lesion underwent malignant change. Conclusions Our results demonstrate that some nerve sheath tumours may contain histologically clear components of both neurofibroma and schwannoma, suggesting that (despite evident and well‐defined clinicopathological differences) these two lesions may be even more closely related than previously recognized. Whether this phenomenon results from a localized microenvironmental change or from a clonal genetic alteration remains unknown.