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Prognostic value of follicular dendritic cells in nodular sclerosing Hodgkin's disease
Author(s) -
Baur A.S.,
MeugéMoraw C.,
Michel G.,
Delacrétaz F.
Publication year - 1998
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1998.00418.x
Subject(s) - pathology , medicine , value (mathematics) , follicular dendritic cells , disease , follicular phase , dermatology , immunology , immune system , t cell , antigen presenting cell , machine learning , computer science
Aims In nodular sclerosing Hodgkin's disease (NSHD), the prognostic relevance of the histopathological grading in two subtypes NSI (low‐grade) and NSII (high‐grade) remains controversial. Analysis of follicular dendritic cells (FDC) may provide new prognostic parameters. Methods and results Tumours from 59 patients with NSHD were studied. Mean follow‐up time was 8 years. Forty‐one cases were classified as NSI and 18 as NSII. FDC were immunostained with the paraffin‐resistant monoclonal antibodies CD21 and CNA.42. We distinguished three patterns in the neoplastic tissue: FDC1, the presence of well‐defined follicle‐like structures ( n = 20); FDC2, the presence of largely destroyed FDC networks ( n = 25); and FDC3, no or a few isolated FDC ( n = 14). The three groups differed clearly regarding the frequency of relapse and the survival. The longest survival was seen in the FDC1 group, the shortest in the FDC3 group, the FDC2 group being intermediate ( P = 0.0025). FDC status was a discriminating prognostic factor for all patients, and within various age and stage categories. Combining the FDC status and the NSI–NSII grading defined the best survival group as FDC1‐NSI. Conclusions Assessment of FDC pattern, associated with histological subtyping, brings valuable data for predicting survival and outcome in NSHD.