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Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype
Author(s) -
Lüttges,
Jörg Vogel,
Menke,
HenneBruns,
Kremer,
Klöppel
Publication year - 1998
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1998.00411.x
Subject(s) - cytokeratin , pathology , pancreas , vimentin , clear cell , adenocarcinoma , carcinoma , biology , phenotype , mutation , cancer , immunohistochemistry , medicine , gene , endocrinology , genetics
Aims Primary clear cell carcinoma of the pancreas resembling metastatic renal carcinoma has only rarely been described. To date it has been poorly characterized as a distinct tumour entity. Methods and results We report a case of clear cell carcinoma in a 53‐year‐old man involving the head of the pancreas and which had a small intraductal papillary component. The clear cell portion comprised about 90% of the tumour mass. It showed predominantly a solid growth pattern with a few scattered tubular structures. Immunocytochemically the tumour cells stained positively for cytokeratins 7, 8, 18 and 19, whereas the reaction for vimentin and neuroendocrine markers was negative. K ‐ras analysis revealed a point mutation at codon 12 with mutation of GGT to GAT. Conclusion The intraductal tumour component of this clear cell carcinoma as well as the cytokeratin pattern and the K ‐ras mutation suggest that this rare type of pancreatic cancer has a ductal phenotype.