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Localized amyloidosis and gastrointestinal lymphoma: a rare association
Author(s) -
Gaia Goteri,
Renzo Ranaldi,
Pileri Sa,
Italo Bearzi
Publication year - 1998
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1998.00409.x
Subject(s) - amyloidosis , pathology , lymphoma , amyloid (mycology) , immunohistochemistry , stomach , marginal zone , ileum , population , immunoglobulin light chain , medicine , b cell , biology , antibody , gastroenterology , immunology , environmental health
Aims: Five cases of primary gastrointestinal (GI) lymphoma (three in the stomach, one in the ileum (IPSID) and one in the colon) associated with localized AL amyloidosis were studied to identify morphological or immunohistochemical features which could explain the amyloid deposition. Methods and results: All the cases were low‐grade marginal zone B‐cell lymphomas; one case of gastric lymphoma and the IPSID also had a high‐grade component. The lymphomas had a monoclonal plasma cell population, with different light and heavy‐chain type expression in the five cases. Plasma cell differentiation was closely associated with the amyloid deposits. The latter were an incidental microscopic finding in one case, but produced tumoral masses in the others. Conclusions: The presence of amyloid in primary GI lymphoma is rare, but can have diagnostic value. In the present study, neither particular features of the lymphomatous proliferation nor specific agents are identified. Therefore, the factors predisposing to amyloid deposition require elucidation.