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Translocation 2;11 in a fibroma of tendon sheath
Author(s) -
Dal Cin,
Raf Sciot,
Jeroen De Smet,
Van den Berghe
Publication year - 1998
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1998.00390.x
Subject(s) - chromosomal translocation , fibroma , tendon , anatomy , medicine , biology , genetics , gene
Aims To determine whether fibromas of tendon sheath represent a reactive fibrosing process or whether they are neoplastic, we investigated the chromosomes of the proliferating cells. A clonally occurring karyotypic abnormality would be an argument in favour of these fibromas being neoplastic. Methods and results A biopsy specimen of a fibroma of tendon sheath was cultured after collagenase exposure leading to dissociation of the tissue. The cultured cells were harvested after 4 days and chromosome analysis done according to standard procedures. Ten out of 20 karyotyped cells showed an identical chromosome abnormality characterized by a t(2;11)(q31–32;q12). The other 10 cells showed a normal 46,XX karyotype. Conclusion The clonally occurring chromosome abnormality found in this fibroma of tendon sheath suggests that this proliferation is neoplastic and not a reactive fibrosing process.