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G‐cell density in the antral mucosa: a feasibility study
Author(s) -
PESCE C.,
ROSSI R.,
LENTI E.,
TANZI R.
Publication year - 1997
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1997.d01-613.x
Subject(s) - antrum , biopsy , degree (music) , sampling (signal processing) , cell , gastric mucosa , biology , pathology , medicine , stomach , physics , optics , biochemistry , detector , acoustics
In this work a new method for gastrin‐secreting cell (G‐cell) density measurement was employed in order to test the hypothesis that G‐cell density of the antral mucosa can be estimated with an acceptable degree of error. The zone of antral mucosa where most G‐cells are located was demarcated, its area was measured and the G‐cells within this area were counted. The variation in the e error of the estimate according to normal distribution theory, and the size of the sampling expected to yield G‐cell density values with a given error were assessed. Our data indicate that a very large surface of the G‐cell zone should be explored in order to estimate G‐cell density with an acceptable degree of error. G‐cell density measurement appears not to be feasible on biopsy specimens or, for routine diagnosis, on gastrectomy specimens.