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Metastatic cancer involving pancreatic duct epithelium and its mimicry of primary pancreatic cancer
Author(s) -
MATSUKUMA S.,
SUDA K.,
ABE H.,
OGATA S.,
WADA R.
Publication year - 1997
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1997.d01-604.x
Subject(s) - pagetoid , pathology , pancreatic cancer , pancreas , medicine , pancreatic duct , metastasis , cancer , adenocarcinoma , pancreatic disease , primary tumor , epithelium , immunohistochemistry
We investigated 47 autopsy cases of metastatic cancer involving the pancreas. Metastatic disease in nine cases involved the pancreatic duct epithelium. In two cases, metastatic cancer cells showed Pagetoid features. In three cases, pancreatic metastatic disease showed solitary proliferation with focal in situ carcinoma‐like lesions mimicking primary pancreatic cancers. Each of these three cases had primary lung adenocarcinomas. Serial sections revealed abrupt borders between the in situ carcinoma‐like lesions and the non‐cancerous epithelium. Primary pancreatic cancers did not show Pagetoid features or abrupt borders between the cancerous and non‐cancerous epithelium. We conclude that the possible diagnosis of pancreatic metastasis should be carefully ruled out in the histological detection of latent primary pancreatic cancer.