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Absence of EBV genome in lymphoepithelioma‐like carcinomas of the larynx
Author(s) -
TARDÍO J.C.,
CRISTÓBAL E.,
BURGOS F.,
MENÁRGUEZ J.
Publication year - 1997
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1997.d01-582.x
Subject(s) - lymphoepithelioma , lymphoepithelioma like carcinoma , epstein–barr virus , larynx , pathology , immunohistochemistry , nasopharyngeal carcinoma , carcinoma , virus , medicine , laryngeal neoplasm , virology , radiation therapy , surgery
Undifferentiated nasopharyngeal carcinomas are universally associated with Epstein‐Barr virus (EBV). This association has been exclusively established in lymphoepithelioma‐like carcinomas in some locations. The relationship between EBV and lymphoepithelioma‐like carcinomas in the larynx is unknown. In none of the few laryngeal lymphoepithelioma‐like carcinomas reported have EBV investigations been carried out. We present here two supraglottic laryngeal lymphoepithelioma‐like carcinomas in which EBV antigens were not demonstrable using immunohistochemical and molecular methods. Our results suggest that EBV may not be involved in laryngeal lymphoepithelioma‐like carcinoma at least in Western patients.