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Nuclear pleomorphism in typical carcinoid tumours of the lung: problems in frozen section interpretation
Author(s) -
SHEPPARD M.N.
Publication year - 1997
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1997.5430778.x
Subject(s) - pleomorphism (cytology) , carcinoid tumour , frozen section procedure , pathology , lung , carcinoid syndrome , carcinoid tumors , medicine , immunohistochemistry
Pulmonary typical carcinoid tumours are generally easy to diagnose with their uniform cells, carcinoid growth pattern and lack of mitoses. However, nuclear pleomorphism, which is common in other neuroendocrine tumours, is not emphasized in pulmonary carcinoid tumours. Three cases of typical carcinoid tumours, because of marked nuclear pleomorphism on frozen section, were misdiagnosed as non‐small cell carcinomas.