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T‐cell intravascular lymphomatosis (angiotropic large cell lymphoma): association with Epstein–Barr viral infection
Author(s) -
AU W.Y.,
SHEK W.H.,
NICHOLLS J.,
TSE K.M.,
TODD D.,
KWONG Y.L.
Publication year - 1997
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1997.3050903.x
Subject(s) - large cell lymphoma , lymphoma , pathology , epstein–barr virus , virology , medicine , biology , virus
Aims: Intravascular lymphomatosis (IVL) is a very rare non‐Hodgkin's lymphoma characterized by proliferation of lymphoma cells in the vascular lumina without involvement of adjacent parenchymal tissue. IVL is predominantly of B‐cell lineage, but occasional cases of T lineage IVL involving almost exclusively the skin have been described. A case of IVL that occurred initially in the epididymis of a patient with an antecedent nasopharyngeal carcinoma was studied to define the clinicopathological features associated with this unique presentation. Methods and results: This lymphoma was studied by standard histological and immunophenotyping methods. The results showed lymphoma cells confined within the blood vessels, which expressed leucocyte common antigen, and T‐cell markers CD3 and UCHL‐1. The T‐cell origin of the IVL prompted investigations for an assciation with Epstein–Barr virus infection (EBV). In‐situ hybridization with digoxigenin‐labelled anti‐sense RNA probes to EBV encoded RNA (EBER) showed strong signals in the nuclei of virtually all of the lymphoma cells. Conclusions: EBV infection of the malignant cells was demonstrated by in‐situ hybridization. This case suggests that T‐cell IVL may be another EBV related human neoplasm. This observation will need to be validated by further studies.