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Angiotropic lymphoma with endocrine involvement
Author(s) -
SHANKS J.H.,
HARRIS M.,
HOWAT A.J.,
FREEMONT A.J.
Publication year - 1997
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1997.2260835.x
Subject(s) - medicine , thyroid , lymphoma , endocrine system , pathology , nodule (geology) , autopsy , chemotherapy , hormone , biology , paleontology
Aims : Two cases of angiotropic high‐grade B‐cell lymphoma are described in which involvement of endocrine glands was a prominent feature. Methods and results : One patient had marked unilateral adrenomegaly due to lymphoma within adrenal blood vessels. He is alive 5 years after presentation following combination chemotherapy. The diagnosis was made at autopsy in the second patient who presented with pyrexia of unknown origin and had hypothyroidism and a thyroid nodule. The thyroid gland and pituitary showed striking involvement by angiotropic lymphoma and the thyroid nodule was a cavernous haemangioma heavily colonized by lymphoma cells. Conclusions : Our cases illustrate endocrine organ manifestations of this rare disease. The condition may respond to combination chemotherapy.