Premium
p53 Protein expression in laryngeal squamous cell carcinomas bearing wild‐type and mutated p53 gene
Author(s) -
PRUNERI G.,
PIGNATARO L.,
FRACCHIOLLA N.S.,
FERRERO S.,
CAPACCIO P.,
CARBONI N.,
OTTAVIANI A.,
MAIOLO A.T.,
NERI A.,
BUFFA R.
Publication year - 1996
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1046/j.1365-2559.1996.d01-466.x
Subject(s) - carcinogenesis , immunohistochemistry , pathology , biology , p53 protein , gene expression , gene , carcinoma , tumor suppressor gene , laryngeal neoplasm , cell , gene mutation , cancer research , basal (medicine) , basal cell , mutation , medicine , genetics , endocrinology , insulin
We performed an immunohistochemical analysis to investigate the expression of p53 protein in a panel of 18 laryngeal squamous cell carcinomas, 15 primary tumours and three in relapse, previously analysed by us for the presence of p53 gene mutations. Dysplastic and/or normal surrounding mucosa was evaluated in 15 different tumours. The results of our study are the following: (1) expression of p53 protein was observed in one out of five tumours positive for p53 gene mutations (20%) and in 10 out of 13 (80%) negative cases; (2), p53 protein over‐expression was frequently observed in normal and/or dysplastic mucosa surrounding either wild‐type (7/11) or mutated p53 tumours (2/4); (3), p53 immunoreactive cells showed a pattern of distribution in normal and mildly/moderately dysplastic mucosa (basal layers), different from that in severely dysplastic mucosa (whole thickness). These data further support the hypothesis that p53 protein over‐expression may be a marker of the earliest phases of multistep tumorigenesis in laryngeal squamous cell carcinoma.